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Circadian Rhythm Disruption as a Root Cause of DepressionCircadian clock gene variants in CLOCK, BMAL1, PER, CRY, NPAS2, and OPN4 interact with light exposure to disrupt hormones, sleep, and mood, increasing risk for depression, anxiety, and seasonal affective disorder

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Furthermore, cagrilintide 2.4 and 4.5 mg reduced triglycerides and very-low-density cholesterol significantly more than pooled placebo, with similar reductions as seen with liraglutide 3.0 mg

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[9] Wilding, J.P.H., et al